[HTML][HTML] Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or …
G Cao, TP Beyer, Y Zhang, RJ Schmidt, YQ Chen… - Journal of lipid …, 2011 - ASBMB
Cholesteryl ester transfer protein (CETP) catalyses the exchange of cholesteryl ester and
triglyceride between HDL and apoB containing lipoprotein particles. The role of CETP in
modulating plasma HDL cholesterol levels in humans is well established and there have
been significant efforts to develop CETP inhibitors to increase HDL cholesterol for the
treatment of coronary artery disease. These efforts, however, have been hampered by the
fact that most CETP inhibitors either have low potency or have undesirable side effects. In …
triglyceride between HDL and apoB containing lipoprotein particles. The role of CETP in
modulating plasma HDL cholesterol levels in humans is well established and there have
been significant efforts to develop CETP inhibitors to increase HDL cholesterol for the
treatment of coronary artery disease. These efforts, however, have been hampered by the
fact that most CETP inhibitors either have low potency or have undesirable side effects. In …
